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Aβ aggregation-IN-1

Aβ aggregation-IN-1 (Compound 1b) is an amyloid-beta precursor protein inhibitor. Aβ aggregation-IN-1 inhibits amyloid-beta aggregation and disaggregation of fibrillogenesis with IC50 values of 3.92 and 7.19 M, respectively. Aβ aggregation-IN-1 also inhibits malondialdehyde formation, augments the intracellular reduced glutathione (GSH) levals and inhibits caspase 3 in neuronal cells[1].

Product Specifications

CAS Number

352525-91-8

UNSPSC

12352005

Hazard Statement

H315, H319, H335

Target

Amyloid-β

Related Pathways

Neuronal Signaling

Field of Research

Neurological Disease

Purity

99.92

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

FC(F)(F)C1=CC=C(/C=C/B(O)O)C=C1

Molecular Formula

C9H8BF3O2

Molecular Weight

215.97

Precautions

H315, H319, H335

References & Citations

[1]Jiménez-Aligaga K, et al. Discovery of alkenylboronic acids as neuroprotective agents affecting multiple biological targets involved in Alzheimer's disease. Bioorg Med Chem Lett. 2013 Jan 15;23 (2) :426-9.

Shipping Conditions

Room Temperature

Storage Conditions

-20°C, 3 years; 4°C, 2 years (Powder)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Available Sizes

Frequently Asked Questions

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