Octamethylcyclotetrasiloxane

Octamethylcyclotetrasiloxane promotes the anchorage-independent growth of MCF-10A and MCF-10F cells. Octamethylcyclotetrasiloxane induces DNA damage, inhibits the expression of DNA-repairing protein BRCA1 under long-term and high-concentration exposure. Octamethylcyclotetrasiloxane exhibits intrinsic estrogenic activity[1].

Product Specifications

CAS Number

[556-67-2]

UNSPSC

12352005

Hazard Statement

H226, H361, H410

Target

DNA/RNA Synthesis

Related Pathways

Cell Cycle/DNA Damage

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Endocrinology

Purity

99.86

Solubility

DMSO : 25 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

C[Si]1(C)O[Si](C)(C)O[Si](C)(C)O[Si](C)(C)O1

Molecular Formula

C8H24O4Si4

Molecular Weight

296.62

Precautions

H226, H361, H410

References & Citations

[1]Farasani A, et al., Exposure to cyclic volatile methylsiloxanes (cVMS) causes anchorage-independent growth and reduction of BRCA1 in non-transformed human breast epithelial cells. J Appl Toxicol. 2017 Apr;37 (4) :454-461.