Cuprizone (Standard)
Cuprizone is a copper chelating agent that forms a deep blue copper ketone complex with copper (II) . The copper ketone reaction can be used in colorimetric tests for the presence of trace copper. Cuprizone can be used to induce some schizophrenia-like behavior in mice. Cuprizone acts on copper enzymes, including SOD1, cytochrome oxidase, and DβH, thereby causing oxidative stress and increasing DA levels in certain brain regions such as the medial prefrontal cortex (PFC) [1].
Product Specifications
CAS Number
370-81-0
UNSPSC
12352211
Target
Dopamine β-hydroxylase
Related Pathways
Metabolic Enzyme/Protease
Field of Research
Neurological Disease
Smiles
O=C(C(N/N=C1CCCCC\1)=O)N/N=C2CCCCC/2
Molecular Formula
C14H22N4O2
Molecular Weight
278.36
References & Citations
[1]Suzuki K, et al. Status spongiosus of CNS and hepatic changes induced by cuprizone (biscyclohexanone oxalyldihydrazone) . Am J Pathol. 1969 Feb;54 (2) :307-25. |[2]Sanadgol N, et al. Alpha-lipoic acid mitigates toxic-induced demyelination in the corpus callosum by lessening of oxidative stress and stimulation of polydendrocytes proliferation. Metab Brain Dis. 2018 Feb;33 (1) :27-37. |[3]M Jake Pushie, et al. Synthesis and structural characterization of copper-cuprizone complexes. Dalton Trans. 2022 Jun 29.|[4]Haiyun Xu, et al. Behavioral and neurobiological changes in C57BL/6 mouse exposed to cuprizone: effects of antipsychotics. Front Behav Neurosci. 2010 Mar 18;4:8.
Shipping Conditions
Room temperature
Scientific Category
Reference Standards
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