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Bis-PEG2-amine-Thalidomide (hydrochloride)

Bis-PEG2-amine-Thalidomide hydrochloride is an E3 ubiquitin ligase cereblon (CRBN) ligand used to recruit the cereblon protein. Bis-PEG2-amine-Thalidomide hydrochloride can be linked to a target protein ligand via a linker to form a PROTAC.

Product Specifications

Target

Ligands for E3 Ligase

Related Pathways

PROTAC

Applications

Cancer-programmed cell death

Field of Research

Cancer

Smiles

NCCOCCOCCOC1=C2C(N(C(C2=CC=C1)=O)C3CCC(N(C3=O)CCOCCOCCN)=O)=O.Cl

Molecular Formula

C25H37ClN4O9

Molecular Weight

573.04

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Isoform

Cereblon

Curated Selection

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