IKZF2-degrader 2
IKZF2-degrader 2 is a selective and orally active IKZF2 molecular glue degrader with DC50 values of 0.5 nM and 1.8 nM in HiBit and FACS. The IKZF2-degrader 2 mediates the ubiquitination and degradation of target proteins by recruiting the CRL4-CRBN E3 ubiquitin ligase. IKZF2-degrader 2 displays moderate degradation against SALL4 with a DC50 of 9 nM but does not induce any significant degradation towards IKZF1, IKZF3, CK1α and GSPT1. IKZF2-degrader 2 can be used for the study of cancer immunology[1].
Product Specifications
CAS Number
[2983841-00-3]
UNSPSC
12352005
Target
IKZF Family; Molecular Glues
Related Pathways
Immunology/Inflammation; PROTAC
Field of Research
Cancer; Inflammation/Immunology
Smiles
O=C1C2=C(CN1C3C(NC(CC3)=O)=O)C(F)=C(C4=C(Cl)C(CN5CCCC5)=C(C=CN6C)C6=N4)C=C2
Molecular Formula
C26H25ClFN5O3
Molecular Weight
509.96
References & Citations
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
IKZF2
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