RAS-IN-5
RAS-IN-5 (Example 2) is a RAS inhibitor. RAS-IN-5 significantly inhibits the interaction between RAF1 and active KRAS mutant protein or HRAS WT protein. RAS-IN-5 significantly inhibits the cell viability of KRAS, NRAS, and EGFR mutant cells. RAS-IN-5 can be used in the research of colorectal cancer, liver cancer, and non-small cell lung cancer[1].
Product Specifications
CAS Number
3061844-70-7
UNSPSC
12352005
Target
Ras
Related Pathways
GPCR/G Protein; MAPK/ERK Pathway
Applications
Cancer-Kinase/protease
Field of Research
Cancer
Smiles
CCN1C2=C3C=C(C4=CC(C[C@@H](C(N5CCC[C@@H](C(OCC(C)(CC3=C1C6=C(C=CC(P(C)(C)=O)=C6)[C@@H](OC)C)C)=O)N5)=O)NC([C@@H](N(C([C@@H]7OCC[C@@H]7C8=CC=CC=C8)=O)C)C(C)C)=O)=CC(O)=C4)C=C2
Molecular Formula
C57H72N5O9P
Molecular Weight
1002.18
References & Citations
[1]TONG, et al. Macrocyclic compounds and therapeutic uses thereof. WO2024222864A1. WIPO (PCT) . 2024-04-26.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
More Discoveries
Explore Other Products
Browse additional items from our catalog
E8949-47C-ML750 100 µL
EIF4E2, NT (Eukaryotic Translation Initiation Factor 4E Type 2, eIF4E Type 2, eIF-4E Type 2, mRNA Cap-binding Protein Type 3, Eukaryotic Translation Initiation Factor 4E-like 3, Eukaryotic Translation Initiation Factor 4E Homologous Protein, mRNA Cap-binding Protein 4EHP, eIF4E-like Protein 4E-LP, EIF4EL3) (MaxLight 750) discontinued
Sign In for Pricing
View Details 151159 100 µg
WRNIP1 (Werner Helicase Interacting Protein 1, WHIP, ATPase WRNIP1, bA420G6.2, FLJ22526, RP11-420G6.2) discontinued
Sign In for Pricing
View Details 
MBS9340317-01 48 Well
Human Zinc finger MYND domain-containing protein 17, ZMYND17 ELISA Kit
Sign In for Pricing
View Details MBS9340317-02 96 Well
Human Zinc finger MYND domain-containing protein 17, ZMYND17 ELISA Kit
Sign In for Pricing
View Details MBS9340317-03 5x 96 Well
Human Zinc finger MYND domain-containing protein 17, ZMYND17 ELISA Kit
Sign In for Pricing
View Details MBS9340317-04 10x 96 Well
Human Zinc finger MYND domain-containing protein 17, ZMYND17 ELISA Kit
Sign In for Pricing
View Details