BG-DBCO
BG-DBCO is a DBCO-conjugated Benzylguanine. BG-DBCO, SNAP-E3 fusion protein and Ligand-N3 form a protein complex. BG-DBCO is conjugated with JQ1-N3-C10 to obtain BG-JQ1. BG-JQ1, administered together with SIAH1-SN mRNA, effectively inhibits the growth of small cell carcinoma of the adrenocortical gland[1].
Product Specifications
CAS Number
[1820756-74-8]
Product Name Alternative
SNAP-DBCO
UNSPSC
12352005
Target
Drug Derivative; Drug Intermediate
Related Pathways
Others
Field of Research
Cancer
Smiles
NC1=NC2=C(C(OCC3=CC=C(C=C3)CNC(CCC(N4CC5=C(C#CC6=CC=CC=C46)C=CC=C5)=O)=O)=N1)N=CN2
Molecular Formula
C32H27N7O3
Molecular Weight
557.60
References & Citations
[1]Teng X, et al. ClickRNA-PROTAC for Tumor-Selective Protein Degradation and Targeted Cancer Therapy. J Am Chem Soc. 2024 Oct 9;146 (40) :27382-27391.
Shipping Conditions
Room temperature
Scientific Category
Dye Reagents
Clinical Information
No Development Reported
Curated Selection
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