Nampt-IN-10
Nampt-IN-10 (Compound 4) is an efficient inhibitor of nicotinamide phosphoribosyltransferase (NAMPT) . Nampt-IN-10 exhibits nanomolar-level inhibitory activity against cell lines such as MDA-MB453, NCI-N87, and NCI-H526. Nampt-IN-10 can be used as an ADC payload, and the ADC constructed with it as the core demonstrates significant anti-tumor activity[1].
Product Specifications
CAS Number
2241015-68-7
UNSPSC
12352005
Target
ADC Payload; NAMPT
Related Pathways
Antibody-drug Conjugate/ADC Related; Metabolic Enzyme/Protease
Applications
Cancer-programmed cell death
Field of Research
Cancer
Smiles
FC(C=C1NC([C@@H]2[C@@H](C3=CN=CC=C3)C2)=O)=C(C=C1)CNC(C4=CC=C(N5CCNCC5)C=C4)=O
Molecular Formula
C27H28FN5O2
Molecular Weight
473.54
References & Citations
[1]Karpov AS, et al. Nicotinamide Phosphoribosyltransferase Inhibitor as a Novel Payload for Antibody-Drug Conjugates. ACS Med Chem Lett. 2018 Jun 28;9 (8) :838-842.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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