1-Chloromethylpyrene

1-Chloromethylpyrene is an alkylating agent that enters the DNA double helix structure through intercalation, forms covalent bonds with electrophilic groups, resulting in DNA cross-linking, thereby inhibiting the proliferation of tumor cells[1].

Product Specifications

CAS Number

[1086-00-6]

UNSPSC

12352005

Hazard Statement

H302+H312+H332, H314

Target

DNA Alkylator/Crosslinker

Related Pathways

Cell Cycle/DNA Damage

Applications

Cancer-programmed cell death

Field of Research

Cancer

Purity

98.0

Smiles

ClCC1=C(C=C2)C3=C4C2=CC=CC4=CC=C3C=C1

Molecular Formula

C17H11Cl

Molecular Weight

250.73

Precautions

H302+H312+H332, H314

References & Citations

[1]Peck RM, et al., Mixed bifunctionality. 4. Antitumor activity of alkylating derivatives of polycyclic aromatic hydrocarbons as a function of structure and of vehicle. J Med Chem. 1972 Jan;15 (1) :68-70.