1-Chloromethylpyrene
1-Chloromethylpyrene is an alkylating agent that enters the DNA double helix structure through intercalation, forms covalent bonds with electrophilic groups, resulting in DNA cross-linking, thereby inhibiting the proliferation of tumor cells[1].
Product Specifications
CAS Number
[1086-00-6]
UNSPSC
12352005
Hazard Statement
H302+H312+H332, H314
Target
DNA Alkylator/Crosslinker
Related Pathways
Cell Cycle/DNA Damage
Applications
Cancer-programmed cell death
Field of Research
Cancer
Purity
98.0
Smiles
ClCC1=C(C=C2)C3=C4C2=CC=CC4=CC=C3C=C1
Molecular Formula
C17H11Cl
Molecular Weight
250.73
Precautions
H302+H312+H332, H314
References & Citations
[1]Peck RM, et al., Mixed bifunctionality. 4. Antitumor activity of alkylating derivatives of polycyclic aromatic hydrocarbons as a function of structure and of vehicle. J Med Chem. 1972 Jan;15 (1) :68-70.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Curated Selection
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