Triisopropyl phosphate

Triisopropyl phosphate inhibits TFF1 and EGR3 gene expression, exhibits anti-estrogenic activity that inhibits Estradiol (HY-B0141) -induced MCF-7 cell proliferation with an EC50 of 341 μM. Triisopropyl phosphate inhibits the estrogen response element (ERE) -stimulated luciferase activity in MVLN cells with an EC50 of 900 μM[1].

Product Specifications

CAS Number

[513-02-0]

UNSPSC

12352211

Hazard Statement

H226, H315, H319, H335, H400

Target

Estrogen Receptor/ERR

Related Pathways

Vitamin D Related/Nuclear Receptor

Field of Research

Endocrinology

Purity

98.0

Smiles

O=P(OC(C)C)(OC(C)C)OC(C)C

Molecular Formula

C9H21O4P

Molecular Weight

224.23

Precautions

H226, H315, H319, H335, H400

References & Citations

[1]Li J, et al., Structure-Oriented Research on the Antiestrogenic Effect of Organophosphate Esters and the Potential Mechanism. Environ Sci Technol. 2020 Nov 17;54 (22) :14525-14534.