1,2-Cyclohexylenedinitrilotetraacetic acid
1,2-Cyclohexylenedinitrilotetraacetic acid (CDTA) is a chelating agent. 1,2-Cyclohexylenedinitrilotetraacetic acid has an ability to remove manganese from brain and liver (in vivo) and their sub-cellular fractions (in vitro), of rats pretreated with manganese sulphate[1].
Product Specifications
CAS Number
482-54-2
Product Name Alternative
CDTA
UNSPSC
12352211
Hazard Statement
H302, H315, H319, H332, H335
Target
Biochemical Assay Reagents
Related Pathways
Others
Applications
Metabolism-sugar/lipid metabolism
Field of Research
Neurological Disease
Purity
99.51
Solubility
DMSO : 5.83 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
C1CCC(C(C1)N(CC(=O)O)CC(=O)O)N(CC(=O)O)CC(=O)O
Molecular Formula
C14H22N2O8
Molecular Weight
346.33
Precautions
H302, H315, H319, H332, H335
References & Citations
[1]Tandon SK, et al. Removal of manganese by chelating agents from brain and liver of manganese treated rats: as in vitro and an in vivo study. Toxicology. 1975 Nov;5 (2) :237-41.|[2]Sun Y, et al., Synthesis and characterization of racemic mixture and meso isomers of bis (trans-2-aminocyclohexyl) aminepentaacetic acid and the stabilities of their Gd (III) complexes. Inorg Chem. 2000 Apr 3;39 (7) :1480-6.|[3]Hazell AS, et al., Alzheimer type II astrocytic changes following sub-acute exposure to manganese and its prevention by antioxidant treatment. Neurosci Lett. 2006 Apr 3;396 (3) :167-71.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, sealed storage, away from moisture)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
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