1,2-Cyclohexylenedinitrilotetraacetic acid

1,2-Cyclohexylenedinitrilotetraacetic acid (CDTA) is a chelating agent. 1,2-Cyclohexylenedinitrilotetraacetic acid has an ability to remove manganese from brain and liver (in vivo) and their sub-cellular fractions (in vitro), of rats pretreated with manganese sulphate[1].

Product Specifications

CAS Number

[482-54-2]

Product Name Alternative

CDTA

UNSPSC

12352211

Hazard Statement

H302, H315, H319, H332, H335

Target

Biochemical Assay Reagents

Related Pathways

Others

Applications

Metabolism-sugar/lipid metabolism

Field of Research

Neurological Disease

Purity

99.51

Solubility

DMSO : 5.83 mg/mL (ultrasonic; warming; heat to 60°C)

Smiles

C1CCC(C(C1)N(CC(=O)O)CC(=O)O)N(CC(=O)O)CC(=O)O

Molecular Formula

C14H22N2O8

Molecular Weight

346.33

Precautions

H302, H315, H319, H332, H335

References & Citations

[1]Tandon SK, et al. Removal of manganese by chelating agents from brain and liver of manganese treated rats: as in vitro and an in vivo study. Toxicology. 1975 Nov;5 (2) :237-41.|[2]Sun Y, et al., Synthesis and characterization of racemic mixture and meso isomers of bis (trans-2-aminocyclohexyl) aminepentaacetic acid and the stabilities of their Gd (III) complexes. Inorg Chem. 2000 Apr 3;39 (7) :1480-6.|[3]Hazell AS, et al., Alzheimer type II astrocytic changes following sub-acute exposure to manganese and its prevention by antioxidant treatment. Neurosci Lett. 2006 Apr 3;396 (3) :167-71.