E3 Ligase Ligand-linker Conjugate 157
E3 Ligase Ligand-linker Conjugate 157 is the conjugate composed of the E3 ligase ligand and the linker. E3 Ligase Ligand-linker Conjugate 157 can be used for synthesis of PROTAC degrader KT-253 (HY-170451) [1].
Product Specifications
CAS Number
[2502189-47-9]
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
E3 Ligase Ligand-Linker Conjugates
Related Pathways
PROTAC
Applications
Cancer-programmed cell death
Field of Research
Cancer
Smiles
O=C(C(N1C2=CC=C(C3CCNCC3)C=C2N(C)C1=O)CC4)NC4=O
Molecular Formula
C18H22N4O3
Molecular Weight
342.39
Precautions
H302, H315, H319, H335
References & Citations
[1]Chutake YK, et al., KT-253, A Novel MDM2 Degrader and p53 Stabilizer, Has Superior Potency and Efficacy Than MDM2 Small Molecule Inhibitors. Mol Cancer Ther. 2024 Dec 9.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Curated Selection
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