GSK3β-IN-3

GSK3β-IN-3 is an ATP-competitive GSK-3β inhibitor (IC50 = 0.90 μM) . GSK3β-IN-3 can reduce the phosphorylation level of tau protein in the BR5706 strain and reduce the deposition of Aβ aggregates in the CL2006 strain, and can be used to research Alzheimer's disease (AD) [1].

Product Specifications

CAS Number

[301359-45-5]

UNSPSC

12352005

Hazard Statement

H302-H315-H319-H335

Target

Amyloid-β; Cytochrome P450; GSK-3; Tau Protein

Related Pathways

Metabolic Enzyme/Protease; Neuronal Signaling; PI3K/Akt/mTOR; Stem Cell/Wnt

Applications

Neuroscience-Neurodegeneration

Field of Research

Neurological Disease

Smiles

CCOC(C1=C(NC(NC1C2=CC=CC=C2Cl)=S)C)=O

Molecular Formula

C14H15ClN2O2S

Molecular Weight

310.80

Precautions

P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

References & Citations

[1]Sukanya S, et al. Exploring 2-Thioxo-1,2,3,4-tetrahydropyrimidines as Dual Acting GSK-3β/Aβ Aggregation Inhibitors: Implications for Alzheimer's Disease Treatment. Drug Dev Res. 2025 Jun;86 (4) :e70112.