Candesartan methyl ester
Candesartan methyl ester (compound 14) is an antagonist for angiotensin II (AII) receptor with an IC50 of 66 nM. Candesartan methyl ester exhibits blood pressure lowering activity in rats models[1].
Product Specifications
CAS Number
[139481-69-9]
UNSPSC
12352005
Hazard Statement
H228, H315, H319
Target
Angiotensin Receptor
Related Pathways
GPCR/G Protein
Applications
Neuroscience-Neuromodulation
Field of Research
Cardiovascular Disease
Purity
99.07
Smiles
CCOC1=NC2=CC=CC(=C2N1CC3=CC=C(C=C3)C4=CC=CC=C4C5=NNN=N5)C(=O)OC
Molecular Formula
C25H22N6O3
Molecular Weight
454.48
Precautions
H228, H315, H319
References & Citations
[1]Kohara Y, et al., Synthesis and angiotensin II receptor antagonistic activities of benzimidazole derivatives bearing acidic heterocycles as novel tetrazole bioisosteres. J Med Chem. 1996 Dec 20;39 (26) :5228-35.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, protect from light)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Isoform
AT2 Receptor
Available Sizes
Curated Selection
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