Candesartan methyl ester

Candesartan methyl ester (compound 14) is an antagonist for angiotensin II (AII) receptor with an IC50 of 66 nM. Candesartan methyl ester exhibits blood pressure lowering activity in rats models[1].

Product Specifications

CAS Number

[139481-69-9]

UNSPSC

12352005

Hazard Statement

H228, H315, H319

Target

Angiotensin Receptor

Related Pathways

GPCR/G Protein

Applications

Neuroscience-Neuromodulation

Field of Research

Cardiovascular Disease

Purity

99.07

Smiles

CCOC1=NC2=CC=CC(=C2N1CC3=CC=C(C=C3)C4=CC=CC=C4C5=NNN=N5)C(=O)OC

Molecular Formula

C25H22N6O3

Molecular Weight

454.48

Precautions

H228, H315, H319

References & Citations

[1]Kohara Y, et al., Synthesis and angiotensin II receptor antagonistic activities of benzimidazole derivatives bearing acidic heterocycles as novel tetrazole bioisosteres. J Med Chem. 1996 Dec 20;39 (26) :5228-35.