4-MDM

4-MDM (4-Methoxydiphenylmethane) is an orally active anti-inflammatory compound that selectively enhances the Leukotriene A4 Hydrolase (LTA4H) aminopeptidase enzyme activity. 4-MDM reduces the neutrophil recruitment in the lung by enhancing the degradation of proline-glycine-proline by LTA4H, thereby reducing inflammation, and does not affect the epoxy-hydrolase activity of LTA4H. 4-MDM can be used for research on lung diseases[1].

Product Specifications

CAS Number

[834-14-0]

Product Name Alternative

4-Methoxydiphenylmethane

UNSPSC

12352005

Hazard Statement

H315, H318, H400

Target

Aminopeptidase

Related Pathways

Metabolic Enzyme/Protease

Field of Research

Others

Purity

99.64

Solubility

DMSO : 200 mg/mL (ultrasonic)

Smiles

COC1=CC=C(C=C1)CC2=CC=CC=C2

Molecular Formula

C14H14O

Molecular Weight

198.26

Precautions

H315, H318, H400

References & Citations

[1]Farhan N, et al. Ultrapressure liquid chromatography-tandem mass spectrometry assay using atmospheric pressure photoionization (UPLC-APPI-MS/MS) for quantification of 4-methoxydiphenylmethane in pharmacokinetic evaluation. J Pharm Biomed Anal. 2016 Sep 5;128:46-52.