6-Methoxyflavone (Standard)
6-Methoxyflavone (Standard) is the analytical standard of 6-Methoxyflavone. This product is intended for research and analytical applications. 6-Methoxyflavone is an orally active methoxyflavone. 6-Methoxyflavone suppresses neuroinflammation in microglia through the inhibition of TLR4/MyD88/p38 MAPK/NF-κB dependent pathways and the activation of HO-1/NQO-1 signaling. 6-Methoxyflavone induces S-phase arrest through the CCNA2/CDK2/p21CIP1 signaling pathway and activates the PERK/EIF2a/ATF4/CHOP pathway in HeLa cells. 6-Methoxyflavone acts as a Flumazenil (HY-B0009) -insensitive positive allosteric modulator at human recombinant α1β2γ2L and α2β2γ2L GABAα receptors. 6-Methoxyflavone inhibits NFAT Translocation into the nucleus and suppresses T cell activation. 6-Methoxyflavone partially restores chronic ethanol-induced behavioral deficits in mice. 6-Methoxyflavone antagonizes chronic constriction injury and diabetes associated neuropathic nociception expression. 6-Methoxyflavone can be used for the study of cancer, inflammation and neurological diseases[1][2][3][4][5][6][7][8].
Product Specifications
CAS Number
26964-24-9
Target
Heme Oxygenase (HO) ; MyD88; NF-κB; p38 MAPK; PERK; Reference Standards; Toll-like Receptor (TLR)
Related Pathways
Cell Cycle/DNA Damage; Immunology/Inflammation; MAPK/ERK Pathway; Metabolic Enzyme/Protease; NF-κB; Others
Field of Research
Cancer; Metabolic Disease; Inflammation/Immunology; Neurological Disease
Smiles
O=C1C=C(C2=CC=CC=C2)OC3=CC=C(OC)C=C13
Molecular Formula
C16H12O3
Molecular Weight
252.27
References & Citations
Shipping Conditions
Room temperature
Scientific Category
Reference Standards
Frequently Asked Questions
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