6-Methoxyflavone (Standard)

6-Methoxyflavone (Standard) is the analytical standard of 6-Methoxyflavone (HY-W097625) . This product is intended for research and analytical applications. 6-Methoxyflavone is an orally active methoxyflavone. 6-Methoxyflavone suppresses neuroinflammation in microglia through the inhibition of TLR4/MyD88/p38 MAPK/NF-κB dependent pathways and the activation of HO-1/NQO-1 signaling. 6-Methoxyflavone induces S-phase arrest through the CCNA2/CDK2/p21CIP1 signaling pathway and activates the PERK/EIF2a/ATF4/CHOP pathway in HeLa cells. 6-Methoxyflavone acts as a Flumazenil (HY-B0009) -insensitive positive allosteric modulator at human recombinant α1β2γ2L and α2β2γ2L GABAα receptors. 6-Methoxyflavone inhibits NFAT Translocation into the nucleus and suppresses T cell activation. 6-Methoxyflavone partially restores chronic ethanol-induced behavioral deficits in mice. 6-Methoxyflavone antagonizes chronic constriction injury and diabetes associated neuropathic nociception expression. 6-Methoxyflavone can be used for the study of cancer, inflammation and neurological diseases[1][2][3][4][5][6][7][8].

Product Specifications

CAS Number

[26964-24-9]

Target

Heme Oxygenase (HO) ; MyD88; NF-κB; p38 MAPK; PERK; Reference Standards; Toll-like Receptor (TLR)

Related Pathways

Cell Cycle/DNA Damage; Immunology/Inflammation; MAPK/ERK Pathway; Metabolic Enzyme/Protease; NF-κB; Others

Field of Research

Cancer; Metabolic Disease; Inflammation/Immunology; Neurological Disease

Smiles

O=C1C=C(C2=CC=CC=C2)OC3=CC=C(OC)C=C13

Molecular Formula

C16H12O3

Molecular Weight

252.27

References & Citations

[1]Zhang C, Quan Y, Yang L, Bai Y, Yang Y. 6-Methoxyflavone induces S-phase arrest through the CCNA2/CDK2/p21CIP1 signaling pathway in HeLa cells. Bioengineered. 2022 Mar;13 (3) :7277-7292. |[2]Arif M, Rauf K, Rehman NU, Tokhi A, Ikram M, Sewell RD. 6-Methoxyflavone and Donepezil Behavioral Plus Neurochemical Correlates in Reversing Chronic Ethanol and Withdrawal Induced Cognitive Impairment. Drug Des Devel Ther. 2022 May 28;16:1573-1593.|[3]Chen WF, et al. 6-methoxyflavone suppresses neuroinflammation in lipopolysaccharide- stimulated microglia through the inhibition of TLR4/MyD88/p38 MAPK/NF-κB dependent pathways and the activation of HO-1/NQO-1 signaling. Phytomedicine. 2022 May;99:154025. |[4]Shahid M, et al. 6-Methoxyflavone antagonizes chronic constriction injury and diabetes associated neuropathic nociception expression. Biochem Biophys Res Commun. 2024 Sep 10;724:150217. |[5]So JS, et al. 6-Methoxyflavone inhibits NFAT translocation into the nucleus and suppresses T cell activation. J Immunol. 2014 Sep 15;193 (6) :2772-83. |[6]Zhang C, et al. The effect and apoptosis mechanism of 6-methoxyflavone in HeLa cells. Biomarkers. 2022 Jul;27 (5) :470-482.|[7]Hall BJ, et al. Modulation of ionotropic GABA receptors by 6-methoxyflavanone and 6-methoxyflavone. Neurochem Res. 2014 Jun;39 (6) :1068-78. |[8]Zhang C, et al. 6-Methoxyflavone inhibits glycolytic energy metabolism in HeLa cells. BMC Cancer. 2025 Apr 17;25 (1) :719.