6-Fluorotryptophan (Standard)

6-Fluorotryptophan, a competitive inhibitor of tryptophan hydroxylase, produced a transient disruption of sleep in rats chronically implanted with EEG recording electrodes[1].

Product Specifications

CAS Number

[7730-20-3]

UNSPSC

12352005

Target

Tryptophan Hydroxylase

Related Pathways

Metabolic Enzyme/Protease

Field of Research

Neurological Disease

Smiles

NC(CC1=CNC2=C1C=CC(F)=C2)C(O)=O

Molecular Formula

C11H11FN2O2

Molecular Weight

222.22

References & Citations

[1]Miwa S, et al. Determination of serotonin turnover in the rat brain using 6-fluorotryptophan. J Neurochem. 1987 May;48 (5) :1577-80. |[2]D Sugden, et al. Changes in the rat sleep-wake cycle produced by DL-6-fluorotryptophan, a competitive inhibitor of tryptophan hydroxylase. Psychopharmacology (Berl) . 1981;74 (4) :369-73.