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DOTAGA-anhydride (GMP)

DOTAGA-anhydride (GMP) is DOTAGA-anhydride (HY-W087187) produced by using GMP guidelines. GMP small molecules works appropriately as an auxiliary reagent for cell therapy manufacture. DOTAGA-anhydride is a DOTA-based metal chelator that can bind to radionuclides and is used to prepare radionuclide drug conjugates (RDCs) . DOTAGA-anhydride has been successfully used for labeling antibodies (e.g., Trastuzumab (HY-P9907) ) . DOTAGA-anhydride can be used for the synthesis of a bimodal tag for Single-photon emission computed tomography (SPECT) or PET/optical imaging[1].

Product Specifications

CAS Number

[1375475-53-8]

UNSPSC

12352005

Target

Radionuclide-Drug Conjugates (RDCs)

Related Pathways

Antibody-drug Conjugate/ADC Related

Field of Research

Cancer

Smiles

O=C(O)CN1CCN(CC(O)=O)CCN(CC(O)=O)CCN(C(CCC(O2)=O)C2=O)CC1

Molecular Formula

C19H30N4O9

Molecular Weight

458.46

References & Citations

[1]Bernhard C, et al. DOTAGA-anhydride: a valuable building block for the preparation of DOTA-like chelating agents. Chemistry. 2012 Jun 18;18 (25) :7834-41.

Shipping Conditions

Room temperature

Scientific Category

GMP Small Molecules

Clinical Information

No Development Reported

Isoform

RDC Bifunctional Chelator

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