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Butein tetramethyl ether

Butein tetramethyl ether (Compound 20) is a potent and selective breast cancer resistance protein/ATP-binding cassette subfamily G member 2 (BCRP/ABCG2) inhibitor. Butein tetramethyl ether has inhibitory potencies against MCF-7 MX and MDCK BCRP cells with IC50 values of 2.2 and 1.03 μM, respectively. Butein tetramethyl ether is promising for research of cancers[1].

Product Specifications

CAS Number

155048-06-9

UNSPSC

12352005

Target

BCRP

Related Pathways

Membrane Transporter/Ion Channel

Field of Research

Cancer

Smiles

COC(C=C1/C=C/C(C2=C(C=C(C=C2)OC)OC)=O)=C(C=C1)OC

Molecular Formula

C19H20O5

Molecular Weight

328.36

References & Citations

[1]Juvale K, et al. Investigation of chalcones and benzochalcones as inhibitors of breast cancer resistance protein. Bioorg Med Chem. 2012 Jan 1;20 (1) :346-55.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Available Sizes

Frequently Asked Questions

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