Butein tetramethyl ether
Butein tetramethyl ether (Compound 20) is a potent and selective breast cancer resistance protein/ATP-binding cassette subfamily G member 2 (BCRP/ABCG2) inhibitor. Butein tetramethyl ether has inhibitory potencies against MCF-7 MX and MDCK BCRP cells with IC50 values of 2.2 and 1.03 μM, respectively. Butein tetramethyl ether is promising for research of cancers[1].
Product Specifications
CAS Number
[155048-06-9]
UNSPSC
12352005
Target
BCRP
Related Pathways
Membrane Transporter/Ion Channel
Field of Research
Cancer
Smiles
COC(C=C1/C=C/C(C2=C(C=C(C=C2)OC)OC)=O)=C(C=C1)OC
Molecular Formula
C19H20O5
Molecular Weight
328.36
References & Citations
[1]Juvale K, et al. Investigation of chalcones and benzochalcones as inhibitors of breast cancer resistance protein. Bioorg Med Chem. 2012 Jan 1;20 (1) :346-55.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Curated Selection
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