3-Amino-5-hydroxybenzoic acid

3-Amino-5-hydroxybenzoic acid is a biosynthetic precursor of the mC7N unit of ansamycin antibiotics, including ansatrienin A and geldanamycin, as well as the antitumor antibiotic mitomycin C. 3-Amino-5-hydroxybenzoic acid may be an early intermediate in the shikimic acid pathway from glucose[1][2].

Product Specifications

CAS Number

[76045-71-1]

Product Name Alternative

AHBA

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

Drug Intermediate

Related Pathways

Others

Field of Research

Infection

Purity

99.83

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

O=C(C1=CC(N)=CC(O)=C1)O

Molecular Formula

C7H7NO3

Molecular Weight

153.14

Precautions

H302, H315, H319, H335

References & Citations

[1]Mao Y, et al. Molecular characterization and analysis of the biosynthetic gene cluster for the antitumor antibiotic mitomycin C from Streptomyces lavendulae NRRL 2564. Chem Biol. 1999 Apr;6 (4) :251-63.|[2]Floss HG, et al. The biosynthesis of 3-amino-5-hydroxybenzoic acid (AHBA), the precursor of mC7N units in ansamycin and mitomycin antibiotics: a review. J Antibiot (Tokyo) . 2011 Jan;64 (1) :35-44.