Alloc-Val-Ala-OH
Alloc-Val-Ala-OH (((Allyloxy) carbonyl) -L-valyl-L-alanine) is a building block in the synthesis of Tesirine, a clinical antibody-drug conjugate (ADC) pyrrolobenzodiazepine (PBD) dimer payload. The Val-Ala will specifically be cleaved by Cathepsin B. The Alloc group is stable to treatment with piperidine and TFA, but can be easily removed under mild conditions by palladium catalyzed allyl transfer.
Product Specifications
CAS Number
[330970-70-2]
Product Name Alternative
((Allyloxy) carbonyl) -L-valyl-L-alanine
UNSPSC
12352211
Hazard Statement
H315, H319
Target
Biochemical Assay Reagents
Related Pathways
Others
Field of Research
Others
Purity
99.75
Smiles
OC([C@H](C)NC([C@H](C(C)C)NC(OCC=C)=O)=O)=O
Molecular Formula
C12H20N2O5
Molecular Weight
272.30
Precautions
H315, H319
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
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