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ZIF-8

ZIF-8 (2-Methylimidazole zinc salt) is an anticancer agent that intrinsically induces pyroptosis through a caspase-1/gasdermin D (GSDMD) -dependent pathway[1].

Product Specifications

CAS Number

59061-53-9

Product Name Alternative

2-Methylimidazole zinc salt

UNSPSC

12352005

Hazard Statement

H302, H314

Target

Caspase; Pyroptosis

Related Pathways

Apoptosis; Immunology/Inflammation

Applications

Cancer-programmed cell death

Field of Research

Cancer

Smiles

CC1=NC=CN1[Zn]N2C=CN=C2C

Molecular Formula

C8H10N4Zn

Molecular Weight

227.59

Precautions

H302, H314

References & Citations

[1]Ding B, et al. ZIF-8 Nanoparticles Evoke Pyroptosis for High-Efficiency Cancer Immunotherapy. Angew Chem Int Ed Engl. 2023 Mar 1;62 (10) :e202215307.

Shipping Conditions

Room Temperature

Storage Conditions

RT, stored under nitrogen

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Available Sizes

Frequently Asked Questions

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