CYP2E1-IN-1
CYP2E1-IN-1 (Compound 10) is an orally active cytochrome P450 2E1 (CYP2E1) inhibitor with a Kd of 7.02 μM, an IC50 of 1.64 μM, and a Ki of 0.897 μM. CYP2E1-IN-1 activates the Nrf2/HO-1 signaling pathway and inhibits ROS production, thereby alleviating pancreatic injury. CYP2E1-IN-1 has significant anti-inflammatory and antioxidant activities and can effectively reduce inflammation and oxidative stress in severe acute pancreatitis (SAP) . CYP2E1-IN-1 can be used in the study of SAP and other inflammatory-related diseases[1].
Product Specifications
CAS Number
[38205-55-9]
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Cytochrome P450; Heme Oxygenase (HO) ; Keap1-Nrf2; Reactive Oxygen Species (ROS)
Related Pathways
Immunology/Inflammation; Metabolic Enzyme/Protease; NF-κB
Applications
COVID-19-immunoregulation
Field of Research
Inflammation/Immunology
Purity
99.95
Solubility
DMSO : 200 mg/mL (ultrasonic)
Smiles
CC(C1=C(N=CS1)C)=O
Molecular Formula
C6H7NOS
Molecular Weight
141.19
Precautions
H302, H315, H319, H335
References & Citations
[1]Qiu J, et al. Discovery of a CYP2E1 inhibitor and its therapeutic potential in severe acute pancreatitis. Eur J Med Chem. 2025 Aug 5;292:117666.
Shipping Conditions
Room Temperature
Storage Conditions
Store at room temperature 3 years
Scientific Category
Reference compound2
Clinical Information
No Development Reported
Available Sizes
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