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Alloc-Val-Ala-pAB

Alloc-Val-Ala-PAB is a peptide cleavable linker used in the synthesis of antibody-drug conjugates (ADCs) . The Val-Ala will specifically be cleaved by Cathepsin B. The Alloc group is stable to treatment with piperidine and TFA, but can be easily removed under mild conditions by palladium catalyzed allyl transfer.

Product Specifications

CAS Number

1343407-91-9

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H335

Target

ADC Linker

Related Pathways

Antibody-drug Conjugate/ADC Related

Applications

Cancer-programmed cell death

Field of Research

Cancer

Purity

99.61

Smiles

OCC1=CC=C(NC([C@@H](NC([C@@H](NC(OCC=C)=O)C(C)C)=O)C)=O)C=C1

Molecular Formula

C19H27N3O5

Molecular Weight

377.43

Precautions

H302, H315, H319, H335

Shipping Conditions

Room Temperature

Storage Conditions

-20°C, 3 years; 4°C, 2 years (Powder)

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Available Sizes

Frequently Asked Questions

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