GABAA receptor modulator-12
GABAA receptor modulator-12 (Compound 5) is a GABAA receptor modulator. GABAA receptor modulator-12 inhibits anesthetic-induced desensitization of GABAA α3β3γ2 receptors with an IC50 of 0.2 μM. GABAA receptor modulator-12 can be used in the research of central nervous system disorders[1].
Product Specifications
CAS Number
[6252-98-8]
UNSPSC
12352005
Hazard Statement
H302-H315-H319-H335
Target
GABA Receptor
Related Pathways
Membrane Transporter/Ion Channel; Neuronal Signaling
Field of Research
Neurological Disease
Smiles
O=C(C1(C(C=CC=C2)=C2CC1)N3)NC3=O
Molecular Formula
C11H10N2O2
Molecular Weight
202.21
Precautions
P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501
References & Citations
[1]Koinas DA, et al. Spiro Hydantoins Can Reverse the Action of Positive Allosteric Modulators on GABAARs. ACS Med Chem Lett. 2025 Sep 30;16 (10) :2078-2083.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Curated Selection
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