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GABAA receptor modulator-12

GABAA receptor modulator-12 (Compound 5) is a GABAA receptor modulator. GABAA receptor modulator-12 inhibits anesthetic-induced desensitization of GABAA α3β3γ2 receptors with an IC50 of 0.2 μM. GABAA receptor modulator-12 can be used in the research of central nervous system disorders[1].

Product Specifications

CAS Number

6252-98-8

UNSPSC

12352005

Hazard Statement

H302-H315-H319-H335

Target

GABA Receptor

Related Pathways

Membrane Transporter/Ion Channel; Neuronal Signaling

Field of Research

Neurological Disease

Smiles

O=C(C1(C(C=CC=C2)=C2CC1)N3)NC3=O

Molecular Formula

C11H10N2O2

Molecular Weight

202.21

Precautions

P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

References & Citations

[1]Koinas DA, et al. Spiro Hydantoins Can Reverse the Action of Positive Allosteric Modulators on GABAARs. ACS Med Chem Lett. 2025 Sep 30;16 (10) :2078-2083.

Shipping Conditions

Room temperature

Scientific Category

Reference compound1

Clinical Information

No Development Reported

Frequently Asked Questions

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