Norharmine

Norharmine is a Harmine analogue and an alkaloid. Norharmine is the inhibitors of MAO-A and DYRK1A. Norharmine has weak inhibitory activity against MAO-A and certain inhibitory activity against DYRK1A[1].

Product Specifications

CAS Number

6253-19-6

UNSPSC

12352005

Hazard Statement

H302-H315-H319-H335

Target

DYRK; Monoamine Oxidase

Related Pathways

Neuronal Signaling; Protein Tyrosine Kinase/RTK

Field of Research

Others

Smiles

COC1=CC(NC2=C3C=CN=C2)=C3C=C1

Molecular Formula

C12H10N2O

Molecular Weight

198.22

Precautions

P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

References & Citations

[1]Wurzlbauer A, et al. How to Separate Kinase Inhibition from Undesired Monoamine Oxidase A Inhibition-The Development of the DYRK1A Inhibitor AnnH75 from the Alkaloid Harmine. Molecules. 2020 Dec 16;25 (24) :5962.