2-Methylquinazolin-4-ol (Standard)

2-Methylquinazolin-4-ol (Standard) is the analytical standard of 2-Methylquinazolin-4-ol. This product is intended for research and analytical applications. 2-Methylquinazolin-4-ol is a potent competitive poly (ADP-ribose) synthetase inhibitor, with a Ki of 1.1 μM. 2-Methylquinazolin-4-ol mammalian aspartate transcarbamylase (ATCase) inhibitor, with 0.20 mM[1][2].

Product Specifications

CAS Number

[1769-24-0]

UNSPSC

12352005

Target

PARP; Reference Standards

Related Pathways

Cell Cycle/DNA Damage; Epigenetics; Others

Field of Research

Others

Smiles

O=C1NC(C)=NC2=C1C=CC=C2

Molecular Formula

C9H8N2O

Molecular Weight

160.18

References & Citations

[1]S Yoshida, et al. Production of 2-methyl-4[3H]-quinazolinone, an inhibitor of poly (ADP-ribose) synthetase, by bacterium. J Antibiot (Tokyo) . 1991 Jan;44 (1) :111-2.|[2]Mahmoud Balbaa, et al. Inhibition of mammalian aspartate transcarbamylase by quinazolinone derivatives. J Enzyme Inhib Med Chem. 2008 Aug;23 (4) :483-92.