6,9-Dichloro-1,2,3,4-tetrahydroacridine

6,9-Dichloro-1,2,3,4-tetrahydroacridine (compound 26) is an intermediate for the synthesis of acetylcholinesterase (AChE) inhibitors, which can be used in the study of Alzheimer's disease[1].

Product Specifications

CAS Number

[5396-25-8]

UNSPSC

12352005

Hazard Statement

H302-H315-H319-H335

Target

Cholinesterase (ChE) ; Drug Intermediate

Related Pathways

Neuronal Signaling; Others

Field of Research

Neurological Disease

Smiles

ClC1=CC2=C(C(Cl)=C3C(CCCC3)=N2)C=C1

Molecular Formula

C13H11Cl2N

Molecular Weight

252.14

Precautions

P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

References & Citations

[1]Recanatini M, et al. SAR of 9-amino-1,2,3,4-tetrahydroacridine-based acetylcholinesterase inhibitors: synthesis, enzyme inhibitory activity, QSAR, and structure-based CoMFA of tacrine analogues. J Med Chem. 2000 May 18;43 (10) :2007-18.