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2-Benzylsuccinic acid (Standard)

2-Benzylsuccinic acid (DL-Benzylsuccinic acid) is an orally active carboxypeptidase A and Nna1 inhibitor. 2-Benzylsuccinic acid reduces cold hyperalgesia. 2-Benzylsuccinic acid can be used for the researches of neuropathic pain, non-alcoholic steatohepatitis[1][2][3][4][5].

Product Specifications

CAS Number

884-33-3

UNSPSC

12352005

Target

Carboxypeptidase

Related Pathways

Metabolic Enzyme/Protease

Field of Research

Metabolic Disease; Neurological Disease

Smiles

O=C(O)C(CC1=CC=CC=C1)CC(O)=O

Molecular Formula

C11H12O4

Molecular Weight

208.21

References & Citations

[1]Mark P. Wentland, et al. 96-Well Plate Colorimetric Assay for Ki Determination of (+/-) -2-Benzylsuccinic Acid, an Inhibitor of Carboxypeptidase A: A Laboratory Experiment in Drug Discovery. J Chem Educ. 2004 Mar 1, 81 (3) :398.|[2]Han MS, et al. A novel strategy for designing irreversible inhibitors of metalloproteases: acetals as latent electrophiles that interact with catalytic nucleophile at the active site. Org Lett. 2000 Oct 5;2 (20) :3149-52.|[3]Wang R, et al. Identification of 2-PMPA as a novel inhibitor of cytosolic carboxypeptidases. Biochem Biophys Res Commun. 2020 Dec 17;533 (4) :1393-1399. |[4]Duan J, et al. Therapeutic targeting of hepatic ACSL4 ameliorates NASH in mice. Hepatology. 2022 Jan;75 (1) :140-153.|[5]Kühlein HN, et al. Nerve injury evoked loss of latexin expression in spinal cord neurons contributes to the development of neuropathic pain. PLoS One. 2011 Apr 29;6 (4) :e19270.

Shipping Conditions

Room temperature

Scientific Category

Reference Standards

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