PD128763
PD128763 is a selective poly (ADP-ribose) polymerase inhibitor. PD128763 results in an enhancement of Streptozotocin (HY-13753) -induced cytotoxicity. PD128763 can be used in leukemia research[1][2].
Product Specifications
CAS Number
[129075-56-5]
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H332, H335
Target
PARP
Related Pathways
Cell Cycle/DNA Damage; Epigenetics
Field of Research
Cancer
Purity
99.57
Smiles
O=C1NCCC=2C1=CC=CC2C
Molecular Formula
C10H11NO
Molecular Weight
161.20
Precautions
H302, H315, H319, H332, H335
References & Citations
[1]Sebolt-Leopold JS, et al. Enhancement of alkylating agent activity in vitro by PD 128763, a potent poly (ADP-ribose) synthetase inhibitor. Int J Radiat Oncol Biol Phys. 1992;22 (3) :619-21. |[2]Yau L, et al. Repression of phosphoenolpyruvate carboxykinase gene activity by insulin is blocked by 3-aminobenzamide but not by PD128763, a selective inhibitor of poly (ADP-ribose) polymerase. Eur J Biochem. 1998 Apr 1;253 (1) :91-100.
Shipping Conditions
Room Temperature
Storage Conditions
Store at room temperature 3 years
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Curated Selection
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