PD128763

PD128763 is a selective poly (ADP-ribose) polymerase inhibitor. PD128763 results in an enhancement of Streptozotocin (HY-13753) -induced cytotoxicity. PD128763 can be used in leukemia research[1][2].

Product Specifications

CAS Number

[129075-56-5]

UNSPSC

12352005

Hazard Statement

H302, H315, H319, H332, H335

Target

PARP

Related Pathways

Cell Cycle/DNA Damage; Epigenetics

Field of Research

Cancer

Purity

99.57

Smiles

O=C1NCCC=2C1=CC=CC2C

Molecular Formula

C10H11NO

Molecular Weight

161.20

Precautions

H302, H315, H319, H332, H335

References & Citations

[1]Sebolt-Leopold JS, et al. Enhancement of alkylating agent activity in vitro by PD 128763, a potent poly (ADP-ribose) synthetase inhibitor. Int J Radiat Oncol Biol Phys. 1992;22 (3) :619-21. |[2]Yau L, et al. Repression of phosphoenolpyruvate carboxykinase gene activity by insulin is blocked by 3-aminobenzamide but not by PD128763, a selective inhibitor of poly (ADP-ribose) polymerase. Eur J Biochem. 1998 Apr 1;253 (1) :91-100.