3-Hydroxy-2-pyrone
3-Hydroxy-2-pyrone (Compound 12d) is a metalloenzyme inhibitor. 3-Hydroxy-2-pyrone shows an inhibition rate of approximately 50% for matrix metalloproteinases (MMP) and the inhibition rate for non-heme iron enzyme 5-lipoxygenase (5-LOX) was over 70% at 1 mM. 3-Hydroxy-2-pyrone also has certain inhibitory activity against copper-dependent enzyme tyrosinase. 3-Hydroxy-2-pyrone can be used for the research of cancer, infection and inflammation[1].
Product Specifications
CAS Number
[496-64-0]
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Lipoxygenase; MMP; Tyrosinase
Related Pathways
Metabolic Enzyme/Protease
Field of Research
Cancer; Infection; Inflammation/Immunology
Purity
99.61
Smiles
O=C1OC=CC=C1O
Molecular Formula
C5H4O3
Molecular Weight
112.08
Precautions
H302, H315, H319, H335
References & Citations
[1]Jacobsen JA, et al. Identifying chelators for metalloprotein inhibitors using a fragment-based approach. J Med Chem. 2011 Jan 27;54 (2) :591-602.
Shipping Conditions
Room Temperature
Storage Conditions
Store at room temperature 3 years
Scientific Category
Reference compound2
Clinical Information
No Development Reported
Available Sizes
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