N- (3-Hydroxyoctanoyl) -DL-homoserine lactone
N- (3-Hydroxyoctanoyl) -DL-homoserine lactone (Compound 40) is a competitive inhibitor of the quorum sensing receptor LuxR with an IC50 value of 4 μM. N- (3-Hydroxyoctanoyl) -DL-homoserine lactone shows selective inhibition toward quorum sensing systems in Gram-negative bacteria like Pseudomonas aeruginosa. N- (3-Hydroxyoctanoyl) -DL-homoserine lactone is promising for research of bacterial infections[1].
Product Specifications
CAS Number
853799-77-6
UNSPSC
12352005
Hazard Statement
H302-H315-H319-H335
Target
Bacterial
Related Pathways
Anti-infection
Field of Research
Infection
Smiles
O=C1C(NC(CC(CCCCC)O)=O)CCO1
Molecular Formula
C12H21NO4
Molecular Weight
243.30
Precautions
P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501
References & Citations
[1]Janssens JC, et al. Small molecules for interference with cell-cell-communication systems in Gram-negative bacteria. Curr Med Chem. 2008;15 (21) :2144-56.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Frequently Asked Questions
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