N- (3-Hydroxyoctanoyl) -DL-homoserine lactone

N- (3-Hydroxyoctanoyl) -DL-homoserine lactone (Compound 40) is a competitive inhibitor of the quorum sensing receptor LuxR with an IC50 value of 4 μM. N- (3-Hydroxyoctanoyl) -DL-homoserine lactone shows selective inhibition toward quorum sensing systems in Gram-negative bacteria like Pseudomonas aeruginosa. N- (3-Hydroxyoctanoyl) -DL-homoserine lactone is promising for research of bacterial infections[1].

Product Specifications

CAS Number

[853799-77-6]

UNSPSC

12352005

Hazard Statement

H302-H315-H319-H335

Target

Bacterial

Related Pathways

Anti-infection

Field of Research

Infection

Smiles

O=C1C(NC(CC(CCCCC)O)=O)CCO1

Molecular Formula

C12H21NO4

Molecular Weight

243.30

Precautions

P261-P264-P270-P271-P280-P302+P352-P304+P340-P305+P351+P338-P330-P362+P364-P403+P233-P405-P501

References & Citations

[1]Janssens JC, et al. Small molecules for interference with cell-cell-communication systems in Gram-negative bacteria. Curr Med Chem. 2008;15 (21) :2144-56.