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Caspase-3/7 Inhibitor I

Caspase-3/7 inhibitor I is a potent and reversible inhibitor of caspase-3 and caspase-7, with Kis of 60 and 170 nM, respectively. Caspase-3/7 inhibitor I can inhibit apoptosis in Camptothecin (HY-16560) -treated Jurkat cells and in chondrocytes[1][2].

Product Specifications

CAS Number

[1110670-49-9]

UNSPSC

12352005

Target

Apoptosis; Caspase

Related Pathways

Apoptosis

Field of Research

Cancer

Purity

98.31

Solubility

DMSO : 100 mg/mL (ultrasonic)

Smiles

O=C1NC2=C(C=C(S(=O)(N3C(COC)CCC3)=O)C=C2)C1=O

Molecular Formula

C14H16N2O5S

Molecular Weight

324.35

References & Citations

[1]Lee D, et, al. Potent and selective nonpeptide inhibitors of caspases 3 and 7 inhibit apoptosis and maintain cell functionality. J Biol Chem. 2000 May 26;275 (21) :16007-14.|[2]Lee D, et, al. Potent and selective nonpeptide inhibitors of caspases 3 and 7. J Med Chem. 2001 Jun 7;44 (12) :2015-26.

Shipping Conditions

Blue Ice

Storage Conditions

-20°C, 3 years (Powder)

Scientific Category

Reference compound1

Clinical Information

Phase 1

Available Sizes

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