Caspase-3/7 Inhibitor I
Caspase-3/7 inhibitor I is a potent and reversible inhibitor of caspase-3 and caspase-7, with Kis of 60 and 170 nM, respectively. Caspase-3/7 inhibitor I can inhibit apoptosis in Camptothecin (HY-16560) -treated Jurkat cells and in chondrocytes[1][2].
Product Specifications
CAS Number
[1110670-49-9]
UNSPSC
12352005
Target
Apoptosis; Caspase
Related Pathways
Apoptosis
Field of Research
Cancer
Purity
98.31
Solubility
DMSO : 100 mg/mL (ultrasonic)
Smiles
O=C1NC2=C(C=C(S(=O)(N3C(COC)CCC3)=O)C=C2)C1=O
Molecular Formula
C14H16N2O5S
Molecular Weight
324.35
References & Citations
[1]Lee D, et, al. Potent and selective nonpeptide inhibitors of caspases 3 and 7 inhibit apoptosis and maintain cell functionality. J Biol Chem. 2000 May 26;275 (21) :16007-14.|[2]Lee D, et, al. Potent and selective nonpeptide inhibitors of caspases 3 and 7. J Med Chem. 2001 Jun 7;44 (12) :2015-26.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, 3 years (Powder)
Scientific Category
Reference compound1
Clinical Information
Phase 1
Available Sizes
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