4-Chloro-2- (trifluoroacetyl) aniline
4-Chloro-2- (trifluoroacetyl) aniline (Compound 10), an analog of Efavirenz (HY-10572), is a Pregnane X receptor (PXR) ligand. 4-Chloro-2- (trifluoroacetyl) aniline has no PXR activation activity without induction of Cyp3a11 mRNA expression[1].
Product Specifications
CAS Number
[154598-53-5]
UNSPSC
12352005
Hazard Statement
H302, H315, H319, H335
Target
Drug Derivative; Pregnane X Receptor (PXR)
Related Pathways
Others; Vitamin D Related/Nuclear Receptor
Field of Research
Others
Purity
97.0
Smiles
O=C(C1=CC(Cl)=CC=C1N)C(F)(F)F
Molecular Formula
C8H5ClF3NO
Molecular Weight
223.58
Precautions
H302, H315, H319, H335
References & Citations
[1]Narayanan B, et al. Probing Ligand Structure-Activity Relationships in Pregnane X Receptor (PXR) : Efavirenz and 8-Hydroxyefavirenz Exhibit Divergence in Activation. ChemMedChem. 2018 Apr 6;13 (7) :736-747.
Shipping Conditions
Room Temperature
Storage Conditions
4°C (Powder, protect from light)
Scientific Category
Reference compound2
Clinical Information
No Development Reported
Available Sizes
Curated Selection
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