Bromodichloromethane

Bromodichloromethane (Dichlorobromomethane) is a type of trihalomethane, commonly found in chlorinated drinking water for disinfection, and is a disinfection by-product. The bromination of bromodichloromethane can cause the formation of mutagenic intermediates through the transformation mediated by glutathione S-transferase (GST) . Bromodichloromethane inhibits the differentiation of human placental trophoblast cells and reduces the secretion of chorionic gonadotropin (CG) . Bromodichloromethane has potential reproductive toxicity and carcinogenicity[1][2].

Product Specifications

CAS Number

[75-27-4]

Product Name Alternative

Dichlorobromomethane

UNSPSC

12352211

Hazard Statement

H302-H315-H318-H335-H351

Target

Glutathione S-transferase

Related Pathways

Metabolic Enzyme/Protease

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Cancer; Metabolic Disease

Smiles

ClC(Br)Cl

Molecular Formula

CHBrCl2

Molecular Weight

163.83

Precautions

P261-P264-P270-P271-P280-P302+P352-P304+P340-P330-P362+P364-P405-P501

References & Citations

[1]Pegram RA, et al. Glutathione S-transferase-mediated mutagenicity of trihalomethanes in Salmonella typhimurium: contrasting results with bromodichloromethane off chloroform. Toxicol Appl Pharmacol. 1997 May;144 (1) :183-8.|[2]Chen J, et al. Bromodichloromethane inhibits human placental trophoblast differentiation. Toxicol Sci. 2004 Mar;78 (1) :166-74.