Rizatriptan (hemisulfate hemihydrate)
Rizatriptan (MK 462) hemisulfate hemihydrate is the agonist for 5-HT1B and 5-HT1D. Rizatriptan hemisulfate hemihydrate has a peripheral vasoconstrictive effect, penetrates the intact blood-brain barrier, and inhibits pain neurotransmission in the central nervous system[1][2].
Product Specifications
CAS Number
[159776-67-7]
Product Name Alternative
MK 462 (hemisulfate hemihydrate)
UNSPSC
12352211
Target
5-HT Receptor
Related Pathways
GPCR/G Protein; Neuronal Signaling
Applications
Neuroscience-Neuromodulation
Field of Research
Neurological Disease
Smiles
O=S(O)(O)=O.CN(C)CCC1=CNC2=C1C=C(C=C2)CN3N=CN=C3.O.[1/2].[1/2]
Molecular Formula
C15H19N5.1/2H2O4S.1/2H2O
Molecular Weight
327.39
References & Citations
[1]Sciberras DG, et al. Initial human experience with MK-462 (rizatriptan) : a novel 5-HT1D agonist. Br J Clin Pharmacol. 1997 Jan;43 (1) :49-54.|[2]Cumberbatch MJ, et al. Rizatriptan has central antinociceptive effects against durally evoked responses. Eur J Pharmacol. 1997 Jun 5;328 (1) :37-40.
Shipping Conditions
Room temperature
Scientific Category
Reference compound1
Clinical Information
Phase 4
Isoform
5-HT1 Receptor
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