Rizatriptan (hemisulfate hemihydrate)

Rizatriptan (MK 462) hemisulfate hemihydrate is the agonist for 5-HT1B and 5-HT1D. Rizatriptan hemisulfate hemihydrate has a peripheral vasoconstrictive effect, penetrates the intact blood-brain barrier, and inhibits pain neurotransmission in the central nervous system[1][2].

Product Specifications

CAS Number

[159776-67-7]

Product Name Alternative

MK 462 (hemisulfate hemihydrate)

UNSPSC

12352211

Target

5-HT Receptor

Related Pathways

GPCR/G Protein; Neuronal Signaling

Applications

Neuroscience-Neuromodulation

Field of Research

Neurological Disease

Smiles

O=S(O)(O)=O.CN(C)CCC1=CNC2=C1C=C(C=C2)CN3N=CN=C3.O.[1/2].[1/2]

Molecular Formula

C15H19N5.1/2H2O4S.1/2H2O

Molecular Weight

327.39

References & Citations

[1]Sciberras DG, et al. Initial human experience with MK-462 (rizatriptan) : a novel 5-HT1D agonist. Br J Clin Pharmacol. 1997 Jan;43 (1) :49-54.|[2]Cumberbatch MJ, et al. Rizatriptan has central antinociceptive effects against durally evoked responses. Eur J Pharmacol. 1997 Jun 5;328 (1) :37-40.