DHICA (Standard)
DHICA (5,6-Dihydroxyindole-2-carboxylic acid) is an intermediate in melanin synthesis and a component of true black pigment, and it’s also a moderately potent GPR35 agonist. DHICA shows an ability to stimulate β-arrestin translocation signaling with an EC50 value of 23.2 μM in the U2OS cell line. DHICA plays a significant role in promoting and protecting against DNA damage[1][2].
Product Specifications
CAS Number
4790-08-3
UNSPSC
12352005
Target
Arrestin; Endogenous Metabolite; GPR35
Related Pathways
GPCR/G Protein; Metabolic Enzyme/Protease
Field of Research
Others
Purity
96.26
Smiles
OC(C1=CC2=C(C=C(C(O)=C2)O)N1)=O
Molecular Formula
C9H7NO4
Molecular Weight
193.16
References & Citations
[1]Huayun Deng, et al. Synthesis and Agonistic Activity at the GPR35 of 5,6-Dihydroxyindole-2-carboxylic Acid Analogues. ACS Med Chem Lett. 2012 Jun 6;3 (7) :550-4.|[2]Maria Carolina Pellosi, et al. Effects of the melanin precursor 5,6-dihydroxy-indole-2-carboxylic acid (DHICA) on DNA damage and repair in the presence of reactive oxygen species. Arch Biochem Biophys. 2014 Sep 1:557:55-64.
Shipping Conditions
Blue Ice
Storage Conditions
-20°C, sealed storage, away from light and moisture
Scientific Category
Reference Standards
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