Phorone

Phorone (Diisopropylidene acetone) is a glutathione (GSH) depletor. Phorone specifically and reversibly depletes free GSH through enzymatic binding (Glutathione S-transferase) (Km = 0.9 mM) . Phorone reversibly reduces the binding and nuclear uptake of glucocorticoid receptors in rat liver, and this effect is related to the temporal changes in GSH levels. Phorone can be used for studying liver toxicity.

Product Specifications

CAS Number

[504-20-1]

Product Name Alternative

Diisopropylidene acetone

UNSPSC

12352211

Hazard Statement

H302, H315, H319, H335

Target

Glutathione S-transferase

Related Pathways

Metabolic Enzyme/Protease

Field of Research

Cancer; Metabolic Disease

Purity

99.89

Smiles

O=C(/C=C(C)/C)/C=C(C)\C

Molecular Formula

C9H14O

Molecular Weight

138.21

Precautions

H302, H315, H319, H335

References & Citations

[1]van Doorn R, et al. Synergistic effects of phorone on the hepatotoxicity of bromobenzene and paracetamol in mice. Toxicology. 1978 Nov;11 (3) :225-33. |[2]Sunahara GI, Chiesa A. Phorone (diisopropylidene acetone), a glutathione depletor, decreases rat glucocorticoid receptor binding in vivo. Carcinogenesis. 1992 Jul;13 (7) :1083-9.