Phorone
Phorone (Diisopropylidene acetone) is a glutathione (GSH) depletor. Phorone specifically and reversibly depletes free GSH through enzymatic binding (Glutathione S-transferase) (Km = 0.9 mM) . Phorone reversibly reduces the binding and nuclear uptake of glucocorticoid receptors in rat liver, and this effect is related to the temporal changes in GSH levels. Phorone can be used for studying liver toxicity.
Product Specifications
CAS Number
[504-20-1]
Product Name Alternative
Diisopropylidene acetone
UNSPSC
12352211
Hazard Statement
H302, H315, H319, H335
Target
Glutathione S-transferase
Related Pathways
Metabolic Enzyme/Protease
Field of Research
Cancer; Metabolic Disease
Purity
99.89
Smiles
O=C(/C=C(C)/C)/C=C(C)\C
Molecular Formula
C9H14O
Molecular Weight
138.21
Precautions
H302, H315, H319, H335
References & Citations
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Natural Products
Clinical Information
No Development Reported
Available Sizes
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KCNJ12, CT (KCNJ12, IRK2, KCNJN1, ATP-sensitive inward rectifier potassium channel 12, Inward rectifier K(+) channel Kir2.2, Inward rectifier K(+) channel Kir2.2v, Potassium channel, inwardly rectifying subfamily J member 12)
KCNJ12, CT (KCNJ12, IRK2, KCNJN1, ATP-sensitive inward rectifier potassium channel 12, Inward rectifier K(+) channel Kir2.2, Inward rectifier K(+) channel Kir2.2v, Potassium channel, inwardly rectifying subfamily J member 12)