Phorone
Phorone (Diisopropylidene acetone) is a glutathione (GSH) depletor. Phorone specifically and reversibly depletes free GSH through enzymatic binding (Glutathione S-transferase) (Km = 0.9 mM) . Phorone reversibly reduces the binding and nuclear uptake of glucocorticoid receptors in rat liver, and this effect is related to the temporal changes in GSH levels. Phorone can be used for studying liver toxicity.
Product Specifications
CAS Number
504-20-1
Product Name Alternative
Diisopropylidene acetone
UNSPSC
12352211
Hazard Statement
H302, H315, H319, H335
Target
Glutathione S-transferase
Related Pathways
Metabolic Enzyme/Protease
Field of Research
Cancer; Metabolic Disease
Purity
99.89
Smiles
O=C(/C=C(C)/C)/C=C(C)\C
Molecular Formula
C9H14O
Molecular Weight
138.21
Precautions
H302, H315, H319, H335
References & Citations
[1]van Doorn R, et al. Synergistic effects of phorone on the hepatotoxicity of bromobenzene and paracetamol in mice. Toxicology. 1978 Nov;11 (3) :225-33. |[2]Sunahara GI, Chiesa A. Phorone (diisopropylidene acetone), a glutathione depletor, decreases rat glucocorticoid receptor binding in vivo. Carcinogenesis. 1992 Jul;13 (7) :1083-9.
Shipping Conditions
Room Temperature
Storage Conditions
-20°C, 3 years; 4°C, 2 years (Powder)
Scientific Category
Natural Products
Clinical Information
No Development Reported
Available Sizes
Frequently Asked Questions
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