Fumaric acid-13C2

Fumaric acid-13C2 is the 13C-labeled Fumaric acid (HY-W015883) . Fumaric acid is an unsaturated dicarbonic acid, an intermediate product of the citric acid cycle that provides intracellular energy in the form of ATP. Fumaric acid exerts anti-inflammatory effects by inhibiting the NF-κB signaling pathway dependent on p38 MAPK. Fumaric acid can be used in the study of pregnancy-induced hypertension[1][2][3].

Product Specifications

CAS Number

[96503-56-9]

UNSPSC

12352211

Hazard Statement

H319

Target

Endogenous Metabolite; Isotope-Labeled Compounds; NF-κB; p38 MAPK

Related Pathways

MAPK/ERK Pathway; Metabolic Enzyme/Protease; NF-κB; Others

Applications

Metabolism-protein/nucleotide metabolism

Field of Research

Metabolic Disease; Inflammation/Immunology; Cardiovascular Disease

Purity

99.9

Smiles

O=[13C](O)/C=C/[13C](O)=O

Molecular Formula

C2 13C2H4O4

Molecular Weight

118.06

Precautions

H319

References & Citations

[1]Whelan DT, et al. Fumaric aciduria: a new organic aciduria, associated with mental retardation and speech impairment. Clin Chim Acta. 1983 Aug 31;132 (3) :301-8. |[2]Roh KB, et al. Fumaric acid attenuates the eotaxin-1 expression in TNF-α-stimulated fibroblasts by suppressing p38 MAPK-dependent NF-κB signaling. Food Chem Toxicol. 2013 Aug;58:423-31.|[3]Zhou Y, et al. Fumaric acid and succinic acid treat gestational hypertension by downregulating the expression of KCNMB1 and TET1. Exp Ther Med. 2021 Oct;22 (4) :1072.