3-Methylquinoline

3-Methylquinoline is a selective cytochrome P450 (CYP1A2) inhibitor with an IC50 of 13 μM. 3-Methylquinoline can reduce the metabolic clearance of CYP1A2 substrate drugs. 3-Methylquinoline can inhibit the activation of carcinogenic precursors[1].

Product Specifications

CAS Number

[612-58-8]

UNSPSC

12352005

Hazard Statement

H312+H332, H315, H318, H335, H351

Target

Cytochrome P450

Related Pathways

Metabolic Enzyme/Protease

Field of Research

Cancer; Metabolic Disease; Inflammation/Immunology; Neurological Disease

Purity

98.83

Smiles

CC1=CN=C2C=CC=CC2=C1

Molecular Formula

C10H9N

Molecular Weight

143.19

Precautions

H312+H332, H315, H318, H335, H351

References & Citations

[1]Korhonen LE, et al. Predictive three-dimensional quantitative structure-activity relationship of cytochrome P450 1A2 inhibitors. J Med Chem. 2005 Jun 2;48 (11) :3808-15.