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SD-169 (Standard)

SD-169 is an orally active ATP-competitive inhibitor of p38α MAPK, with an IC50 of 3.2 nM. SD-169 also weakly inhibits p38β MAPK with an IC50 of 122 nM. SD-169 prevents the development and progression of diabetes by inhibiting T cell infiltration and activation[1].

Product Specifications

CAS Number

1670-87-7

UNSPSC

12352005

Target

P38 MAPK

Related Pathways

MAPK/ERK Pathway

Field of Research

Metabolic Disease

Smiles

O=C(C1=CC2=C(NC=C2)C=C1)N

Molecular Formula

C9H8N2O

Molecular Weight

160.18

References & Citations

[1]Medicherla S, et al. Preventive and therapeutic potential of p38 alpha-selective mitogen-activated protein kinase inhibitor in nonobese diabetic mice with type 1 diabetes. J Pharmacol Exp Ther. 2006 Jul;318 (1) :99-107.

Shipping Conditions

Room temperature

Scientific Category

Reference Standards

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