2,4-Di-tert-butylphenol-d19

2,4-Di-tert-butylphenol-d19 (2,4-DTBP-d19) is the deuterium labeled 2,4-Di-tert-butylphenol (HY-W014589) . 2,4-Di-tert-butylphenol (2,4-DTBP) is an orally active RXRα activator and a human estrogen receptor ligand with anti-inflammatory and antioxidant activities, which can induce apoptosis in tumor cells. 2,4-Di-tert-butylphenol can activate the RXRα subtype in LXRα/RXRα, PPARγ/RXRα, and hormone receptor β/RXRα. 2,4-Di-tert-butylphenol also has antiviral and antifungal activities and has the potential to inhibit Aβ-induced neurotoxicity. 2,4-Di-tert-butylphenol can be used as an intermediate in the preparation of antioxidants and UV stabilizers, and is also used in the manufacture of drugs and fragrances[1][2][3].

Product Specifications

CAS Number

[1577233-55-6]

Product Name Alternative

2,4-DTBP-d19

UNSPSC

12352005

Target

Amyloid-β; Apoptosis; Endogenous Metabolite; Fungal; Isotope-Labeled Compounds; RAR/RXR

Related Pathways

Anti-infection; Apoptosis; Metabolic Enzyme/Protease; Neuronal Signaling; Others; Vitamin D Related/Nuclear Receptor

Applications

Neuroscience-Neurodegeneration

Field of Research

Cancer; Infection; Inflammation/Immunology; Neurological Disease

Smiles

[2H]C([2H])([2H])C(C([2H])([2H])[2H])(C1=CC(C(C([2H])([2H])[2H])(C([2H])([2H])[2H])C([2H])([2H])[2H])=CC([2H])=C1O)C([2H])([2H])[2H]

Molecular Formula

C14H3D19O

Molecular Weight

225.44

References & Citations

[1]Zhao F, et al. Natural sources and bioactivities of 2, 4-di-tert-butylphenol and its analogs[J]. Toxins, 2020, 12 (1) : 35.|[2]Ren XM, et al. 2,4-Di-tert-butylphenol Induces Adipogenesis in Human Mesenchymal Stem Cells by Activating Retinoid X Receptors. Endocrinology. 2023 Feb 11;164 (4) :bqad021.|[3]Choi SJ, et al. 2,4-Di-tert-butylphenol from sweet potato protects against oxidative stress in PC12 cells and in mice. J Med Food. 2013 Nov;16 (11) :977-83.