9,10-Phenanthrenequinone
9,10-Phenanthrenequinone is an inhibitor of claudin-5/CLDN5 that induces apoptosis via a NO synthase/ROS-dependent mechanism. 9,10-Phenanthrenequinone also promotes endothelial barrier dysfunction by promoting caspase activation and DNA fragmentation, and reducing CLDN5 expression and proteasomal proteolysis[1].
Product Specifications
CAS Number
84-11-7
UNSPSC
12352005
Hazard Statement
H319, H400
Target
Claudin
Related Pathways
Cytoskeleton
Applications
Cancer-programmed cell death
Field of Research
Cancer
Purity
99.95
Solubility
DMSO : 10 mg/mL (ultrasonic; warming; heat to 60°C)
Smiles
O=C1C2=CC=CC=C2C3=CC=CC=C3C1=O
Molecular Formula
C14H8O2
Molecular Weight
208.21
Precautions
H319, H400
References & Citations
[1]Kamase K, et al. 9,10-Phenanthrenequinone provokes dysfunction of brain endothelial barrier through down-regulating expression of claudin-5. Toxicology. 2021 Sep;461:152896.
Shipping Conditions
Room Temperature
Storage Conditions
Store at room temperature 3 years
Scientific Category
Reference compound1
Clinical Information
No Development Reported
Available Sizes
Frequently Asked Questions
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